Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases.

@article{Flammang1986AcetylCA,
  title={Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases.},
  author={T J Flammang and Fred F. Kadlubar},
  journal={Carcinogenesis},
  year={1986},
  volume={7 6},
  pages={919-26}
}
The metabolic activation of several carcinogenic N-hydroxy (N-OH)-arylamines by cytosolic S-acetyl coenzyme A (AcCoA)-dependent enzymes was examined in tissues and species susceptible to arylamine carcinogenesis. Comparisons of the AcCoA-dependent activity were also made with known cytosolic arylhydroxamic acid-dependent acyltransferases and with the ability of different acyl donors to mediate the binding of N-OH-arylamines to DNA. With rat hepatic cytosol, AcCoA-dependent DNA binding was… CONTINUE READING
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