Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.

  title={Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.},
  author={Tory M. Hagen and Russell T Ingersoll and Carol M Wehr and Jens Lykkesfeldt and Vladim{\'i}r Vinarsk{\'y} and James C. Bartholomew and Min Ho Song and Bruce N. Ames},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 16},
Mitochondrial function and ambulatory activity were monitored after feeding old rats acetyl-L-carnitine (ALCAR). Young (3-5 mo) and old (22-28 mo) rats were given a 1.5% (wt/vol) solution of ALCAR in their drinking water for 1 mo, were sacrificed, and their liver parenchymal cells were isolated. ALCAR supplementation significantly reverses the age-associated decline of mitochondrial membrane potential, as assessed by rhodamine 123 staining. Cardiolipin, which declines significantly with age, is… CONTINUE READING
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