Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties.

@article{Ghirardi2005AcetylLCarnitinePA,
  title={Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties.},
  author={Orlando Ghirardi and Pietro Lo Giudice and Claudio Pisano and Mario Vertechy and Augusta Bellucci and Loredana Vesci and Sante Cundari and Mariarosaria Miloso and Laura Maria Rigamonti and Gabriella Nicolini and Claudio Zanna and Paolo Carminati},
  journal={Anticancer research},
  year={2005},
  volume={25 4},
  pages={2681-7}
}
BACKGROUND Oxaliplatin (OHP) is severely neurotoxic and induces the onset of a disabling sensory peripheral neuropathy. Acetyl-L-carnitine (ALC), a natural compound with neuroprotective action, was tested to determine whether it plays a protective role in OHP-induced neuropathy. MATERIALS AND METHODS Peripheral neuropathy was induced in Wistar rats, and the effect of OHP alone or in combination with ALC was assessed, using behavioral and neurophysiological methods. Moreover, ALC interference… CONTINUE READING
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