Acetyl-CoA synthetase overexpression in Escherichia coli demonstrates more efficient acetate assimilation and lower acetate accumulation: a potential tool in metabolic engineering

@article{Lin2005AcetylCoASO,
  title={Acetyl-CoA synthetase overexpression in Escherichia coli demonstrates more efficient acetate assimilation and lower acetate accumulation: a potential tool in metabolic engineering},
  author={Henry K. Lin and Natalia M. Castro and George N. Bennett and Ka-Yiu San},
  journal={Applied Microbiology and Biotechnology},
  year={2005},
  volume={71},
  pages={870-874}
}
The overexpression of acetyl-CoA (CoA) synthetase (ACS) in Escherichia coli showed significant reduction in acetate during glucose fermentation. It also greatly enhanced acetate assimilation when acetate was used as a carbon source. These features are ideal for applications in metabolic engineering. ACS overexpression can be strategically applied to reduce acetate byproduct, recover wasted carbon, and redirect carbon flux toward more favorable pathways. The native acs gene was cloned and… CONTINUE READING

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Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield

  • H Lin, GN Bennett, San K-Y
  • Metab Eng
  • 2005
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