Acetyl-CoA and acetylcholine metabolism in nerve terminal compartment of thiamine deficient rat brain.

@article{JankowskaKulawy2010AcetylCoAAA,
  title={Acetyl-CoA and acetylcholine metabolism in nerve terminal compartment of thiamine deficient rat brain.},
  author={Agnieszka Jankowska-Kulawy and Hanna Bielarczyk and Tadeusz Pawełczyk and Małgorzata Wr{\'o}blewska and Andrzej Szutowicz},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 2},
  pages={
          333-42
        }
}
The decrease of pyruvate and ketoglutarate dehydrogenase complex activities is the main cause of energy and acetyl-CoA deficits in thiamine deficiency-evoked cholinergic encephalopathies. However, disturbances in pathways of acetyl-CoA metabolism leading to appearance of cholinergic deficits remain unknown. Therefore, the aim of this work was to investigate alterations in concentration and distribution of acetyl-CoA and in acetylcholine metabolism in brain nerve terminals, caused by thiamine… CONTINUE READING
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