Acetonitrile serum concentrations and cyanide blood levels in a case of suicidal oral acetonitrile ingestion.

@article{Michaelis1991AcetonitrileSC,
  title={Acetonitrile serum concentrations and cyanide blood levels in a case of suicidal oral acetonitrile ingestion.},
  author={Hans Christoph Michaelis and Conrad J. Clemens and Harald Kijewski and Hartmud Neurath and Anna Eggert},
  journal={Journal of toxicology. Clinical toxicology},
  year={1991},
  volume={29 4},
  pages={
          447-58
        }
}
Acute acetonitrile toxicity is mainly dependent on the release of cyanide via hepatic metabolism. Although evaluated in animals, few data are available concerning the toxicokinetic parameters of acetonitrile and acetonitrile-liberated cyanide in human. This paper reports a case of suicidal oral acetonitrile ingestion of about 5 mL without severe symptoms of intoxication in a previously healthy adult male with a body weight of 60 kg. Acetonitrile serum concentrations as well as cyanide blood… 
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15 Citations
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Methods Citations
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15 Citations

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Citation Type

Delayed cyanide poisoning following acetonitrile ingestion.
TLDR
A case of deliberate self-poisoning by a 39-year-old woman resulting in cyanide poisoning 11 hours later which was successfully treated by repeated boluses of sodium nitrite and thiosulphate is described.
Suicide attempt with acetonitrile ingestion in a nursing mother
TLDR
The clinical management must involve the use of CN antidotes for more than 24 h depending on the symptoms and blood levels of ACN, and the data showed the possible existence of a close relationship between plasma and breast milk levels.
Determination of acetonitrile and cyanide in rat blood: application to an experimental study.
TLDR
The coefficients of variation of 10% or less obtained for intra- and interassay precision indicate the precision of these analytical methods and the systematic errors, all less than 5%, indicate that the methods are quite accurate.
Diagnosis and misdiagnosis of poisoning with the cyanide precursor acetonitrile: nail polish remover or nail glue remover?
Massive rhabdomyolysis and acute renal failure after acetonitrile exposure.
TLDR
A 35-year-old previously healthy man suffered from vomiting, convulsion and consciousness loss 15 hours after exposure to acetonitrile, and antidote therapy against cyanide poisoning was given.
Simultaneous determination of hydrogen cyanide and volatile aliphatic nitriles by headspace gas chromatography, and its application to an in vivo study of the metabolism of acrylonitrile in the rat
TLDR
It is possible to clarify the cause of cyanide poisoning using HS-GC analysis, when someone has taken volatile nitriles, in an in vivo study of VCN metabolism.
An acetonitrile-related death.
TLDR
The cause of death was determined to be acetonitrile poisoning although the source of the acetonijile was not discovered.
Breath testing and personal exposure--SIFT-MS detection of breath acetonitrile for exposure monitoring.
TLDR
SIFT-MS testing of air and breath made it possible to determine that occupational exposure to acetonitrile in the chemistry laboratory was the cause of increased exhaled acetonijile.
Acetonitrile as a possible marker of current cigarette smoking
TLDR
Acetonitrile in blood appears to be highly specific and a moderately sensitive marker of cigarette smoking with a dose-effect relationship, and shows promise as a marker of current cigarette exposure.
Cyanide Fatalities: Case Studies of Four Suicides and One Homicide
TLDR
The discussion focuses on the circumstances, metabolic changes, pathophysiology, blood levels, diagnosis, and management of cyanide poisoning.
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References

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WIRKUNGSBEDINGUNGEN VON BLAUSÄURE UND SCHWEFELWASSERSTOFF UND MOGLICHKEITEN DER VERGIFTUNGSBEHANDLUNG
Blausaure und Schwefelwasserstoff wirken, wenn sic gasformig inhaliert werden auBerordentlich schnell and beide sind hochtoxische Verbindungen mit einer Wirkun in etwa der gleichen GroBenordnung.…
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