Acetogenic bacteria: what are the in situ consequences of their diverse metabolic versatilities?

  title={Acetogenic bacteria: what are the in situ consequences of their diverse metabolic versatilities?},
  author={Harold L Drake and Steven L. Daniel and Kirsten K{\"u}sel and Carola Matthies and Carla H. Kuhner and Susanna A. Braus-Stromeyer},
The four decades of the now classic studies by Harland G. Wood and Lars G. Ljungdahl lead to the resolution of the autotrophic acetyl‐CoA 'Wood/Ljungdahl' pathway of acetogenesis. This pathway is the hallmark of acetogens, but is also used by other bacteria, including methanogens and sulfate‐reducing bacteria, for both catabolic and anabolic purposes. Thus, the pathway is wide spread in nature and plays an important role in the global turnover of carbon. Because most historical studies with… 

Energetics and Application of Heterotrophy in Acetogenic Bacteria

The energetic advantages of coupling CO2 reduction to fermentations that exploit otherwise-inaccessible substrates and the ecological advantages, as well as the biotechnological applications of the heterotrophic metabolism of acetogens are discussed.

Ecological consequences of the phylogenetic and physiological diversities of acetogens

This mini-review will highlight a few of the physiological and ecological realities of acetogens, and will focus on: (i) metabolic diversities and regulation, (ii) phylogenetic diversity and molecular ecology, and the capacity of acetogenic species to cope with oxic conditions under both laboratory and in situ conditions.

Old Acetogens, New Light

Tributes are paid to those who discovered acetogens and acetogenesis, and toThose who resolved the acetyl‐CoA pathway to highlight the ecology and physiology of acetogens within the framework of their scientific roots.

Ancient Metabolisms of a Thermophilic Subseafloor Bacterium

The genome of a novel acetogen from a thermal suboceanic aquifer olivine biofilm in the basaltic crust of the Juan de Fuca Ridge is described whose genome suggests it may utilize an ancient chemosynthetic lifestyle.

The unique biochemistry of methanogenesis.

  • U. Deppenmeier
  • Biology, Chemistry
    Progress in nucleic acid research and molecular biology
  • 2002

2,3-Butanediol Metabolism in the Acetogen Acetobacterium woodii

The metabolite analysis and enzymatic measurements revealed that 2,3-butanediol is oxidized in an NAD+-dependent manner to acetate via the intermediates acetoin, acetaldehyde, and acetyl coenzyme A, which means the metabolism of A. woodii requires the Wood-Ljungdahl pathway.

The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).

This first genome sequence of an acetogenic bacterium provides important information related to how acetogens engage their extreme metabolic diversity by switching among different carbon substrates and electron donors/acceptors and how they conserve energy by anaerobic respiration.

MINIREVIEW Energy Conservation in Acetogenic Bacteria

A number of organisms have evolved additional mechanisms to increase their ATP yield because they rely mostly on substrate level phosphorylation (SLP), and the energy yield ranges from 1 to 4 mol of ATP per mol of hexose fermented.

Overcoming Energetic Barriers in Acetogenic C1 Conversion

The pathway, the energetics of the pathway and ways to overcome energetic barriers in acetogenic C1 conversion are described, which set the stage for acetogens as production platforms for a wide range of bioproducts from CO2.



Acetogenesis from Carbon Dioxide in Termite Guts

During microbial fermentation in the gut of certain termites, in particular, acetogens not only appear to constitute the primary H2 sink, but their production of acetate from H2 + CO2 makes a major contribution to termite nutrition.

Energetics of Acetogenesis from C1 Units

This chapter will deal mainly with the utilization of C1 substrates and the energy conservation coupled to the synthesis of acetate from these substrates.

Variations of the Acetyl-CoA Pathway in Diversely Related Microorganisms That Are Not Acetogens

Five aspects of the acetyl-CoA pathway and its variants which are of general biological relevance are briefly discussed.

Acetogenesis and the Rumen: Syntrophic Relationships

Evidence exists that Clostridium thermoaceticum may also reduce protons and, hence, produce H2 under certain conditions, and proton-reducing acetogens may also utilize the acetyl CoA pathway for CO2 reduction (see Chapter 1).

Diversity, Ecology, and Isolation of Acetogenic Bacteria

It is no doubt that homoacetogens are the most versatile physiological group among the anaerobic bacteria the authors know.

The Acetyl-CoA Pathway and the Chemiosmotic Generation of ATP during Acetogenesis

A spore-forming anaerobic bacterium that formed acetate from CO2 and H2 is isolated and named Clostridium aceticum, which could grow on a synthetic medium of glucose, glutamic acid, biotin, pyridoxamine, and pantothenic acid.

Effect of nitrate on the autotrophic metabolism of the acetogens Clostridium thermoautotrophicum and Clostridium thermoaceticum

Results indicated that nitrate blocked the reduction of CO2 to the methyl and carbonyl levels and indicated that C. thermoautotrophicum and C.thermoaceticum cannot engage the carbon-fixing capacities of the acetyl-CoA pathway in the presence of nitrate.

The Sodium Ion Cycle in Acetogenic and Methanogenic Bacteria: Generation and Utilization of a Primary Electrochemical Sodium Ion Gradient

Homoacetogenic bacteria convert 1 mol of glucose to 3 mol of acetate via glycolysis and acetyl-CoA pathway, which is sufficient to ensure the energy supply of the cells during heterotrophic acetogenesis.

CO Dehydrogenase and the Central Role of This Enzyme in the Fixation of Carbon Dioxide by Anaerobic Bacteria

Our planet requires a continual source of fixed carbon because heterotrophic organisms produce energy by oxidizing the organic carbon to CO2, thereby depleting the organic carbon. Reconversion of CO2

Nitrate as a preferred electron sink for the acetogen Clostridium thermoaceticum

The results demonstrated that nitrate was preferentially used as an electron sink under conditions that were otherwise acetogenic, nitrate dissimilation was energy conserving and growth supportive, and nitrate-coupled utilization of O-methyl groups conserved more energy than acetogenic O demethylation.