Acetoacetyl-CoA synthetase is essential for normal neuronal development.

@article{Hasegawa2012AcetoacetylCoASI,
  title={Acetoacetyl-CoA synthetase is essential for normal neuronal development.},
  author={Shinya Hasegawa and Hiroki Kume and Sayuri Iinuma and Masahiro Yamasaki and Nobuaki Takahashi and Tetsuya Fukui},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={427 2},
  pages={
          398-403
        }
}
Cholesterol and fatty acids are essential, abundant components of neuronal tissue. Acetoacetyl-CoA synthetase (AACS) is a ketone body-utilizing enzyme for the synthesis of cholesterol and fatty acids and is highly expressed in the brain. In this study, we investigated the regulation of AACS during neurite outgrowth to clarify the physiological role of AACS in neurogenesis. Messenger RNA levels and the expression of AACS were increased during neurite outgrowth in Neuro-2a cells. The expression… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Cdc42: an important regulator of neuronal morphology.

  • The international journal of biochemistry & cell biology
  • 2012
VIEW 1 EXCERPT

Critical time window of neuronal cholesterol synthesis during neurite outgrowth.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2012