• DOI:10.1152/AJPHEART.00473.2002
Corpus ID: 21841710

Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism.

@article{Squires2003AcetoacetateAB,
  title={Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism.},
  author={Jeffrey E. Squires and Jie Sun and J. Caffrey and D. Yoshishige and R. Mallet},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 4},
  pages={
          H1340-7
        }
}

• Jeffrey E. Squires, Jie Sun, +2 authors R. Mallet
• Published 2003
• Chemistry, Medicine
• American journal of physiology. Heart and circulatory physiology

Blunted beta-adrenergic inotropism in stunned myocardium is restored by pharmacological (N-acetylcysteine) and metabolic (pyruvate) antioxidants. The ketone body acetoacetate is a natural myocardial fuel and antioxidant that improves contractile function of prooxidant-injured myocardium. The impact of acetoacetate on postischemic cardiac function and beta-adrenergic signaling has never been reported. To test the hypothesis that acetoacetate restores contractile performance and beta-adrenergic… Expand

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