Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism.

@article{Squires2003AcetoacetateAB,
  title={Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism.},
  author={Jeffrey E. Squires and Jie Sun and J. Caffrey and D. Yoshishige and R. Mallet},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 4},
  pages={
          H1340-7
        }
}
Blunted beta-adrenergic inotropism in stunned myocardium is restored by pharmacological (N-acetylcysteine) and metabolic (pyruvate) antioxidants. The ketone body acetoacetate is a natural myocardial fuel and antioxidant that improves contractile function of prooxidant-injured myocardium. The impact of acetoacetate on postischemic cardiac function and beta-adrenergic signaling has never been reported. To test the hypothesis that acetoacetate restores contractile performance and beta-adrenergic… Expand
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References

SHOWING 1-10 OF 53 REFERENCES
Pyruvate potentiates beta-adrenergic inotropism of stunned guinea-pig myocardium.
  • 28
Antioxidant properties of pyruvate mediate its potentiation of beta-adrenergic inotropism in stunned myocardium.
  • 73
Adenosine receptor blockade enhance glycolysis in hypoperfused guinea-pig myocardium.
  • 18
  • PDF
Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals.
  • 64
Energetic modulation of cardiac inotropism and sarcoplasmic reticular Ca2+ uptake.
  • 53
Metabolically Based Treatment of Stunned Myocardium
  • 9
Modification of cardiac β-adrenoceptor mechanisms by H2O2.
  • 27
Glucose requirement for postischemic recovery of perfused working heart.
  • 121
...
1
2
3
4
5
...