Acetic acid-guided biopsies after magnifying endoscopy compared with random biopsies in the detection of Barrett's esophagus: a prospective randomized trial with crossover design.

@article{Hoffman2006AceticAB,
  title={Acetic acid-guided biopsies after magnifying endoscopy compared with random biopsies in the detection of Barrett's esophagus: a prospective randomized trial with crossover design.},
  author={Arthur E. Hoffman and Ralf Kiesslich and Alexandra Bender and Markus F Neurath and Bernhard Nafe and G{\"u}nter Herrmann and Michael Jung},
  journal={Gastrointestinal endoscopy},
  year={2006},
  volume={64 1},
  pages={1-8}
}
BACKGROUND In contrast to standard video endoscopy, magnifying endoscopy after local acetic acid application enables recognition of mucosal surface architecture. OBJECTIVE To investigate the diagnostic yield of magnifying endoscopy with acetic acid-targeted biopsies compared to random, 4-quadrant biopsies. DESIGN Prospective randomized trial (ratio 1:1) with crossover design. SETTING Two referral hospitals in Germany. PATIENTS Thirty-one patients with Barrett's esophagus or visible… CONTINUE READING

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