Acetazolamide prevents vacuolar myopathy in skeletal muscle of K(+) -depleted rats.

@article{Tricarico2008AcetazolamidePV,
  title={Acetazolamide prevents vacuolar myopathy in skeletal muscle of K(+) -depleted rats.},
  author={Domenico Tricarico and S Lovaglio and Antonietta Mele and Giuseppe Rotondo and Enzo Mancinelli and Giovanni Meola and Diana Conte Camerino},
  journal={British journal of pharmacology},
  year={2008},
  volume={154 1},
  pages={183-90}
}
BACKGROUND AND PURPOSE Acetazolamide and dichlorphenamide are carbonic anhydrase (CA) inhibitors effective in the clinical condition of hypokalemic periodic paralysis (hypoPP). Whether these drugs prevent vacuolar myopathy, which is a pathogenic factor in hypoPP, is unknown. The effects of these drugs on the efflux of lactate from skeletal muscle were also… CONTINUE READING