Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis.

AIM To study effects of acetazolamide on aquaporin-1 (AQP(1)) protein expression and angiogenesis. METHODS Establishing Lewis-lung-carcinoma model, the localization of AQP(1) in tumor tissues was investigated by immunohistochemical methods; The biological activity of acetazolamide was detected by endothelial cells proliferation test (MTT) assay and… CONTINUE READING