Acetazolamide in the Treatment of Seizures

@article{Reiss1996AcetazolamideIT,
  title={Acetazolamide in the Treatment of Seizures},
  author={William G. Reiss and Karen S. Oles},
  journal={Annals of Pharmacotherapy},
  year={1996},
  volume={30},
  pages={514 - 519}
}
OBJECTIVE: TO summarize the pharmacology, pharmacokinetics, efficacy, and safety of acetazolamide and to evaluate its therapeutic role in patients with epilepsy. DATA SOURCES: A computerized search of the MEDLINE (OVID) database (1966–1994) was used to identify publications regarding acetazolamide. The MEDLINE search was supplemented by information from textbooks. STUDY SELECTION: Included were English-language review articles, clinical trials, cohort studies, and case reports. Topics… Expand
Outside the box: Medications worth considering when traditional antiepileptic drugs have failed
TLDR
Meds efficacious for seizure control, despite primary indications for other diseases, are discussed as treatment options in patients who have failed therapy with traditional antiepileptic drugs (AEDs). Expand
Long-term effectiveness and side effects of acetazolamide as an adjunct to other anticonvulsants in the treatment of refractory epilepsies
TLDR
The idea that AZA may be a useful adjunct drug in selected patients with refractory symptomatic localization-related epilepsies is reinforced. Expand
Combining antiepileptic drugs—Rational polytherapy?
TLDR
The availability of an increasing number of pharmacologically distinct AEDs has produced a modest improvement in prognosis with combination therapy, which will encourage the clinician to persevere with continued pharmacological manipulation when other therapeutic options have been tried or are not appropriate. Expand
Therapy in Sleep-Related Hypermotor Epilepsy (SHE)
TLDR
In patients showing an unsatisfactory response to monotherapy, topiramate (TPM), lacosamide (LCM) and acetazolamide (ACZ) could be reasonable add-on strategies, and current treatment recommendations are based only on case reports and small series. Expand
Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial
TLDR
The majority of participants in the Idiopathic Intracranial Hypertension Treatment Trial were able to tolerate acetazolamide above 1 g/d for 6 months and appears to have an acceptable safety profile at dosages up to 4 g/D in the treatment of idiopathics intracranial hypertension. Expand
Diuretics as Antiepileptic Drugs: Should We Go with the Flow?
lthough acetazolamide has been used as a fourth-line anticonvulsant since the days when there were only three other anticonvulsants from which to choose (1), diuretics are not the first class ofExpand
The carbonic anhydrase inhibitor acetazolamide exerts antidystonic effects in the dt(sz) mutant hamster.
TLDR
Data are in line with several case reports from patients with paroxysmal dystonia, suggesting that acetazolamide can be useful in the treatment of this movement disorder. Expand
Treatment of epilepsy: existing therapies and future developments.
TLDR
Understanding of the condition is advancing rapidly but many challenges remain in discovering and developing better AEDs, and pharmacotherapy remains the mainstay of treatment and is effective in most patients. Expand
Low-Dose Acetazolamide in the Treatment of Premenstrual Dysphoric Disorder: A Case Series
TLDR
It is suggested that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments, and GABAergic mechanisms may be involved in counteracting PMDD symptoms. Expand
Mechanisms of action of currently used antiseizure drugs
TLDR
Attempts are being made to engineer specific small molecule, antisense and gene therapies that functionally reverse or structurally correct pathogenic defects in epilepsy syndromes, but targeted therapies will remain elusive for the vast majority of epilepsies until their causes are identified. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 70 REFERENCES
Toxic interaction between acetazolamide and salicylate: Case reports and a pharmacokinetic explanation
TLDR
Pharmacokinetic studies in four volunteers showed that the plasma protein binding and renal clearance of acetazolamide were significantly reduced during chronic salicylate dosing, suggesting an interaction with aspirin. Expand
Further evaluation of acetazolamide (diamox) in treatment of epilepsy.
TLDR
Acetazolamide Administered by mouth in a series of 126 patients with various forms of epilepsy, it gave practically complete control of seizures and a 90 to 99% reduction of seizures in an additional 12 cases, suggesting that the drug may act rather directly on the metabolism of cerebral neurones. Expand
Use of Acetazolamide as an Adjunct to Carbamazepine in Refractory Partial Seizures
Summary: Acetazolamide (Diamox) (AZM) was evaluated as an adjunct to carbamazepine (CBZ) monotherapy in 48 refractory partial seizure patients at a tertiary care referral center. Patient ages rangedExpand
Sulfonamide hypersensitivity and acetazolamide.
TLDR
A search of the MEDLINE and TOXLINE data bases revealed more than 2000 references to acetazolamide, but not a single report of cross-sensitivity, and the manufacturer of Diamox (Lederle Laboratories) has only a few reports on file of sulfonamide-type hypersensitivity reactions to Diam ox. Expand
Chronic acetazolamide monotherapy in the treatment of juvenile myoclonic epilepsy
TLDR
Among the 51 patients treated with acetazolamide (AZM) either because of a poor response to conventional antiepileptic drugs or to avoid valproate-associated adverse effects, most tolerated AZM very well; 5, however, developed renal calculi. Expand
Fatal bone marrow depression after treatment with acetazolamide (diamox).
TLDR
To this case is added one of severe bone marrow depression with agranulocytosis, thrombocytopenia, and anemia, which resulted in death after one month of therapy with acetazolamide in a daily dose of 250 mg. Expand
The pharmacokinetics of acetazolamide during CAPD.
TLDR
The first pharmacokinetic study of acetazolamide in a patient undergoing continuous ambulatory peritoneal dialysis in a Type I diabetic with end-stage renal disease undergoing CAPD, which found the patient was very lethargic during therapy, a possible manifestation of acetzolamide toxicity. Expand
Acetazolamide and Salicylate Interaction in the Elderly: A Case Report
TLDR
A brief case report illustrating an adverse interaction between acetazolamide and salicylate is presented, followed by a discussion of the pharmacokinetics of combined dosing. Expand
Mechanism of the anticonvulsant action of acetazoleamide, a carbonic anhydrase inhibitor.
TLDR
It is anticipated that if potent congeners of acetazoleamide are developed which can reach higher concentrations in the brain, they will exhibit more marked anticonvulsant activity and may have greater clinical value in the treatment of epilepsy. Expand
Mechanisms of Tolerance to the Anticonvulsant Effects of Acetazolamide in Mice: Relation to the Activity and Amount of Carbonic Anhydrase in Brain
TLDR
The data suggest that the activity of CAII is regulated by several mechanisms in brain tissues and that preservation of its activity is vital to the normal functioning of the brain. Expand
...
1
2
3
4
5
...