Acetazolamide does not disrupt limb regenerate morphogenesis in the salamander, Plethodon cinereus.


Acetazolamide, a potent and highly specific inhibitor of carbonic anhydrase, is teratogenic in mammalian embryos and when administered during early limb development causes unique limb defects in a time- and dose-dependent manner. The regenerating urodele limb is often considered to be a good experimental analog of limb development and, if it employs the… (More)


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