Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis

@article{Bhatt2013AcetateSI,
  title={Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis},
  author={Dhaval P. Bhatt and Heidi M. Houdek and John A. Watt and Thad A. Rosenberger},
  journal={Neurochemistry International},
  year={2013},
  volume={62},
  pages={296-305}
}
Acetate supplementation in rats increases plasma acetate and brain acetyl-CoA levels. Although acetate is used as a marker to study glial energy metabolism, the effect that acetate supplementation has on normal brain energy stores has not been quantified. To determine the effect(s) that an increase in acetyl-CoA levels has on brain energy metabolism, we measured brain nucleotide, phosphagen and glycogen levels, and quantified cardiolipin content and mitochondrial number in rats subjected to… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest.

  • Journal of cellular physiology
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 78 REFERENCES

Preferential utilization of acetate by astrocytes is attributable to transport.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1998
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Brain glycogen re-awakened.

  • Journal of neurochemistry
  • 2004
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

A simple analysis of the "phosphocreatine shuttle".

  • The American journal of physiology
  • 1984
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Mitochondrial energetics and therapeutics.

  • Annual review of pathology
  • 2010
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…