Acetate reduces microglia inflammatory signaling in vitro.

  title={Acetate reduces microglia inflammatory signaling in vitro.},
  author={Mahmoud L. Soliman and Kendra Lynn Puig and Colin Combs and Thad A. Rosenberger},
  journal={Journal of neurochemistry},
  volume={123 4},
Acetate supplementation increases brain acetyl-CoA and histone acetylation and reduces lipopolysaccharide (LPS)-induced neuroglial activation and interleukin (IL)-1β expression in vivo. To determine how acetate imparts these properties, we tested the hypothesis that acetate metabolism reduces inflammatory signaling in microglia. To test this, we measured the effect acetate treatment had on cytokine expression, mitogen-activated protein kinase (MAPK) signaling, histone H3 at lysine 9 acetylation… CONTINUE READING
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