Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes.

@article{Rivire2009AcetatePI,
  title={Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes.},
  author={Laurent Rivi{\`e}re and Patrick J. F. Moreau and Stefan Allmann and Matthias Hahn and Marc Biran and Nicolas Plazolles and Jean-Michel Franconi and Michael Boshart and Fr{\'e}d{\'e}ric Bringaud},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 31},
  pages={
          12694-9
        }
}
Acetyl-CoA produced in mitochondria from carbohydrate or amino acid catabolism needs to reach the cytosol to initiate de novo synthesis of fatty acids. All eukaryotes analyzed so far use a citrate/malate shuttle to transfer acetyl group equivalents from the mitochondrial matrix to the cytosol. Here we investigate how this acetyl group transfer occurs in the procyclic life cycle stage of Trypanosoma brucei, a protozoan parasite responsible of human sleeping sickness and economically important… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

Similar Papers

Loading similar papers…