Acetate inhibits NFAT activation in T cells via importin beta1 interference.

@article{Ishiguro2007AcetateIN,
  title={Acetate inhibits NFAT activation in T cells via importin beta1 interference.},
  author={Kazuhiro Ishiguro and Takafumi Ando and Osamu Maeda and Naoki Ohmiya and Yasumasa Niwa and Hidemi Goto},
  journal={European journal of immunology},
  year={2007},
  volume={37 8},
  pages={2309-16}
}
Acetate is a principal short chain fatty acid produced by bacterial fermentation in the colon and a major end product of alcohol metabolism. In the present study, we assessed the effects of acetate on T cell activation and found that acetate inhibited NFAT activation but not NF-kappaB activation. Moreover, acetate impaired the nuclear translocation of NFAT but not that of NF-kappaB. Unlike cyclosporin A (CsA), acetate did not affect the dephosphorylation of NFAT and calcineurin activity… CONTINUE READING