Acetate-dependent mechanisms of inborn tolerance to ethanol.

@article{Zimatkin2011AcetatedependentMO,
  title={Acetate-dependent mechanisms of inborn tolerance to ethanol.},
  author={Sergey M. Zimatkin and Nikolay A Oganesian and Yury V Kiselevski and Richard A. Deitrich},
  journal={Alcohol and alcoholism},
  year={2011},
  volume={46 3},
  pages={
          233-8
        }
}
AIMS To clarify the role of acetate in neurochemical mechanisms of the initial (inborn) tolerance to ethanol. METHODS Rats with low and high inborn tolerance to hypnotic effect of ethanol were used. In the brain region homogenates (frontal and parietal cortex, hypothalamus, striatum, medulla oblongata) and brain cortex synaptosomes, the levels of acetate, acetyl-CoA, acetylcholine (AcH), the activity of pyruvate dehydrogenase (PDG) and acetyl-CoA synthetase were examined. RESULTS It has… CONTINUE READING

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