Acetaminophen safety and hepatotoxicity – where do we go from here?

@article{Amar2007AcetaminophenSA,
  title={Acetaminophen safety and hepatotoxicity – where do we go from here?},
  author={P. Amar and Eugene R Schiff},
  journal={Expert Opinion on Drug Safety},
  year={2007},
  volume={6},
  pages={341 - 355}
}
Acetaminophen has been widely used for > 50 years in the treatment of pain and fever and provides for the safe and effective relief of these symptoms. In a small minority of patients, however, acetaminophen is responsible for life-threatening liver injury and accounts for up to 50% of all adult cases of acute liver failure in the US. Although approximately two-thirds of adult overdoses are associated with suicide attempts, many are inadvertent, often due to the use of multiple acetaminophen… 
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One of the most commonly used antipyretic and analgesic drug in the world, which has no adverse effect when used at the therapeutic dose, paracetamol is associated with both intentional and unintentional poisoning.
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References

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TLDR
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TLDR
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