Acetaminophen pharmacokinetics after overdose.


Concentrations of acetaminophen in serum and urinary excretion rates of acetaminophen glucuronide and acetaminophen sulfate were determined in a 15-year-old female who had ingested an overdose which resulted in the absorption of an estimated 9.92 g of acetaminophen. The results obtained are in reasonably good agreement with predictions of acetaminophen disposition based upon a previously developed pharmacokinetic model of capacity-limited acetaminophen elimination, but additional studies are needed to refine that model.

Cite this paper

@article{Slattery1981AcetaminophenPA, title={Acetaminophen pharmacokinetics after overdose.}, author={J T Slattery and Jeffrey R. Koup and Gweneth Levy}, journal={Clinical toxicology}, year={1981}, volume={18 1}, pages={111-7} }