Acetaminophen ototoxicity after acetaminophen/hydrocodone abuse: Evidence from two parallel in vitro mouse models

  title={Acetaminophen ototoxicity after acetaminophen/hydrocodone abuse: Evidence from two parallel in vitro mouse models},
  author={Joshua G. Yorgason and G. Kalinec and W. Luxford and F. Warren and F. Kalinec},
  journal={Otolaryngology–Head and Neck Surgery},
  pages={814 - 819.e2}
  • Joshua G. Yorgason, G. Kalinec, +2 authors F. Kalinec
  • Published 2010
  • Medicine
  • Otolaryngology–Head and Neck Surgery
  • Objective: Acetaminophen/hydrocodone, a commonly used analgesic preparation, has been linked to rapidly progressing sensorineural hearing loss in human patients. The cellular and molecular mechanisms underlying the ototoxic effects of this drug combination are currently unknown, but are usually associated with high doses of hydrocodone. This study was aimed at identifying the specific agent responsible for hearing loss from toxic killing of cochlear sensory cells. Study Design: Dose-response… CONTINUE READING
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