Acetaminophen nephrotoxicity in CD-1 mice. I. Evidence of a role for in situ activation in selective covalent binding and toxicity.

@article{Hart1994AcetaminophenNI,
  title={Acetaminophen nephrotoxicity in CD-1 mice. I. Evidence of a role for in situ activation in selective covalent binding and toxicity.},
  author={S. G. Hart and William P. Beierschmitt and D. Stuart Wyand and Edward A. Khairallah and Steven D. Cohen},
  journal={Toxicology and applied pharmacology},
  year={1994},
  volume={126 2},
  pages={
          267-75
        }
}
Acetaminophen (APAP) administration (600 mg/kg, ip) to 18-hr-fasted, 3-month-old male CD-1 mice results in necrosis of the renal convoluted proximal tubules. To selectively inhibit APAP activation in the kidney but not in the liver, 10-week-old male CD-1 mice were castrated under ether anesthesia and allowed to recover for a minimum of 2 weeks before use. Microsomal activation of APAP in vitro was monitored by trapping the APAP-derived electrophile as an N-acetylcysteine conjugate. Production… CONTINUE READING
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