Acetaminophen nephrotoxicity: studies on renal acetylation and deacetylation.

  title={Acetaminophen nephrotoxicity: studies on renal acetylation and deacetylation.},
  author={H M Carpenter and Gilbert H. Mudge},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={218 1},
Acetaminophen (N-acetyl-p-aminophenol; APAP) inhibits both the acetylation and uptake of p-aminohippurate (PAH) by slices of mouse kidney cortex; p-aminophenol (PAP) is more potent than APAP in inhibiting the acetylation of PAH, but has no effect on uptake of PAH. Since PAP itself is acetylated by the kidney, the action of PAP on the acetylation of PAH might be competitive. However, from kinetic analysis the inhibition is principally noncompetitive in nature. In studies on deacetylation, PAP… CONTINUE READING

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