Acetaminophen metabolism, cytotoxicity, and genotoxicity in rat primary hepatocyte cultures.

@article{Milam1985AcetaminophenMC,
  title={Acetaminophen metabolism, cytotoxicity, and genotoxicity in rat primary hepatocyte cultures.},
  author={K M Milam and James L. Byard},
  journal={Toxicology and applied pharmacology},
  year={1985},
  volume={79 2},
  pages={342-7}
}
Acetaminophen (APAP) metabolism, cytotoxicity, and genotoxicity were measured in primary cultures of rat hepatocytes. Although 3 mM APAP caused a slight increase in cellular release of lactate dehydrogenase into the culture medium, cellular glutathione concentration (an index of APAP metabolism) was reduced by 50%. APAP at 7 mM was significantly more toxic to these hepatocytes and had a similar but more marked effect on glutathione concentrations. In spite of its cytotoxicity, neither dose of… CONTINUE READING

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