Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.

  title={Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.},
  author={Laxmikant S. Deshpande and Robert J Delorenzo},
  volume={22 1},
Status epilepticus (SE) is a major neurological disorder and SE survivors often develop acquired epilepsy and cognitive deficits. Thus, it is important to stop SE and limit brain damage. However, rapid pharmacoresistance develops to anticonvulsants as seizure duration lengthens. Recently, acetaminophen was reported to increase endocannabinoid levels by its conversion to AM 404. Further, cannabinoids are potent anticonvulsants. Here we investigated whether acetaminophen would block SE-like… CONTINUE READING

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