Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.

@article{MuthSelbach1999AcetaminophenIS,
  title={Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.},
  author={U S Muth-Selbach and Irmgard Tegeder and Kay Brune and Gerd 7 Geisslinger},
  journal={Anesthesiology},
  year={1999},
  volume={91 1},
  pages={231-9}
}
BACKGROUND Prostaglandin play a pivotal role in spinal nociceptive processing. At therapeutic concentrations, acetaminophen is not a cyclooxygenase inhibitor. inhibitor. Thus, it is antinociceptive without having antiinflammatory or gastrointestinal toxic effects. This study evaluated the role of spinal prostaglandin E2 (PGE2) in antinociception produced by intraperitoneally administered acetaminophen. METHODS The PGE2 concentrations in the dorsal horn of the spinal cord were measured after… CONTINUE READING
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