Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes.

@article{Boulares2002AcetaminophenIA,
  title={Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes.},
  author={A Hamid Boulares and Anna J Zoltoski and Bogdan A Stoica and Olivier Cuvillier and Mark E. Smulson},
  journal={Pharmacology & toxicology},
  year={2002},
  volume={90 1},
  pages={38-50}
}
Acetaminophen is a widely used analgesic and antipyretic drug that exhibits toxicity at high doses to the liver and kidneys. This toxicity has been attributed to cytochrome P-450-generated metabolites which covalently modify target proteins. Recently, acetaminophen, in its unmetabolized form, has been shown to affect a variety of cells and tissues, for instance, testicular and lymphoid tissues and lymphocyte cell lines. The effects on cell viability of acetaminophen at a concentration… CONTINUE READING

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