Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice.

@article{Meyers1988AcetaminopheninducedIO,
  title={Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice.},
  author={Lynda L. Meyers and William P. Beierschmitt and Edward A. Khairallah and Steven D. Cohen},
  journal={Toxicology and applied pharmacology},
  year={1988},
  volume={93 3},
  pages={
          378-87
        }
}
Morphological changes are observed in mitochondria early in the course of acetaminophen (APAP) hepatotoxicity. In order to determine if functional deficits also occur, this study examined the effect of APAP, in vivo and in vitro, on mitochondrial respiration in fasted, male CD-1 mice (3-4 months old). After a hepatotoxic dose of APAP (600 mg/kg, po), when glutamate was used as the respiratory substrate, state 3 respiration (ADP-stimulated) was inhibited and this was reflected in a decreased… CONTINUE READING
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