Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.

@article{Ayoub2004AcetaminopheninducedHI,
  title={Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.},
  author={Samir S Ayoub and Regina M. Botting and Sarita Goorha and Paul Richard Colville-Nash and Derek Albert Willoughby and Leslie R. Ballou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 30},
  pages={
          11165-9
        }
}
Acetaminophen is a widely used antipyretic analgesic, reducing fever caused by bacterial and viral infections and by clinical trauma such as cancer or stroke. In rare cases in humans, e.g., in febrile children or HIV or stroke patients, acetaminophen causes hypothermia while therapeutic blood levels of the drug are maintained. In C57/BL6 mice, acetaminophen caused hypothermia that was dose related and maximum (>2 degrees C below normal) with a dose of 300 mg/kg. The reduction and recovery of… CONTINUE READING

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