Acetaminophen hepatotoxicity. An alternative mechanism.

  title={Acetaminophen hepatotoxicity. An alternative mechanism.},
  author={Gerald Rosen and W. Vance Singletary and Elmer J. Rauckman and Paul G. Killenberg},
  journal={Biochemical pharmacology},
  volume={32 13},
Alcohol-fed hamsters were used to study the mechanism by which acetaminophen initiates hepatotoxicity. Animals maintained on an ethanol-containing diet (Group B) exhibited an increased mortality rate after administration of acetaminophen (400 mg/kg) as compared to control hamsters (Group A). However, in those animals in which the ethanol-containing diet had been replaced by the control diet 24 hr before receiving acetaminophen (Group C), significant protection against acetaminophen toxicity was… CONTINUE READING