Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.

  title={Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.},
  author={Leonard B. Seeff and Brenda A. Cuccherini and Hyman J. Zimmerman and Edgar Adler and Stanley B. Benjamin},
  journal={Annals of internal medicine},
  volume={104 3},
We have treated 6 chronic alcoholics and identified an additional 19 reported in the literature who developed severe hepatotoxicity from acetaminophen taken in apparently moderate doses. The clinical disease in these 25 patients had a characteristic pattern: mild to moderate jaundice; mild to severe coagulopathy; and strikingly abnormal aminotransferase levels, values inconsistent with either acute alcoholic hepatitis or viral hepatitis. The possible causes for the injury from ostensibly… CONTINUE READING