Acetaminophen hepatotoxicity: the first 35 years.

  title={Acetaminophen hepatotoxicity: the first 35 years.},
  author={Barry H. Rumack},
  journal={Journal of toxicology. Clinical toxicology},
  volume={40 1},
  • Barry H. Rumack
  • Published 2002 in Journal of toxicology. Clinical toxicology
The acetaminophen nomogram including its uses and limitations is discussed as well as the development of the N-acetylcysteine protocol. While it has taken many years to elucidate the genetic variability and true multiplicity of the cytochrome P450 "mixed function oxidase system" many publications early on looked at the enzyme system as a single entity. Numerous articles indicated that barbiturates, anticonvulsants, and others could induce "P450" and add to the toxicity of acetaminophen. It… CONTINUE READING
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Decreased Serum Interleukin-6 (IL-6) Following Acute Acetaminophen (APAP) Overdose Is Associated with Hepatic Injury

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Ethanol Effect on Glutathione Transporter as a Mechanism for Acetaminophen Hepatotoxicity in the Alcoholic

  • J. T. Slattery
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