Acetaminophen developmental pharmacokinetics in premature neonates and infants: a pooled population analysis.

@article{Anderson2002AcetaminophenDP,
  title={Acetaminophen developmental pharmacokinetics in premature neonates and infants: a pooled population analysis.},
  author={Brian J Anderson and Richard A van Lingen and Tom G Hansen and Yuan-Chi Lin and Nick Hg Holford},
  journal={Anesthesiology},
  year={2002},
  volume={96 6},
  pages={1336-45}
}
BACKGROUND The aim of this study was to describe acetaminophen developmental pharmacokinetics in premature neonates through infancy to suggest age-appropriate dosing regimens. METHODS A population pharmacokinetic analysis of acetaminophen time-concentration profiles in 283 children (124 aged < or = 6 months) reported in six studies was undertaken using nonlinear mixed-effects models. Neonates and infants were given either single or multiple doses of four different formulations: oral elixir… CONTINUE READING