Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes.

  title={Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes.},
  author={Jaana E. Laine and Seppo Auriola and Markku J Pasanen and Risto O Juvonen},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={39 1},
Acetaminophen is a widely used analgesic antipyretic agent. When used at low doses, it is a safe drug, but at higher doses it can cause acute hepatic necrosis in humans and experimental animals. The key mechanism in the hepatotoxicity is cytochrome P450 (CYP)-catalysed formation of the reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI) that is capable of binding to cellular macromolecules and in that way an LC/MS liquid chromatography/mass spectrometry (LC/MS) method was developed to… CONTINUE READING
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