Acetaminophen Reduces Social Pain

@article{DeWall2010AcetaminophenRS,
  title={Acetaminophen Reduces Social Pain},
  author={C. Nathan DeWall and Geoff Macdonald and Gregory D. Webster and Carrie L. Masten and Roy F. Baumeister and Caitlin Powell and David J. Y. Combs and David Ryan Schurtz and Tyler F. Stillman and Dianne M. Tice and Naomi I. Eisenberger},
  journal={Psychological Science},
  year={2010},
  volume={21},
  pages={931 - 937}
}
Pain, whether caused by physical injury or social rejection, is an inevitable part of life. These two types of pain—physical and social—may rely on some of the same behavioral and neural mechanisms that register pain-related affect. To the extent that these pain processes overlap, acetaminophen, a physical pain suppressant that acts through central (rather than peripheral) neural mechanisms, may also reduce behavioral and neural responses to social rejection. In two experiments, participants… 

Figures and Tables from this paper

Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen.
TLDR
These data are the first to show that forgiveness and acetaminophen have interactive effects on experiences of social pain, which is one of the most common and impactful of all human experiences.
Social pain and the brain: controversies, questions, and where to go from here.
TLDR
Research supporting the physical-social pain overlap is summarized, three criticisms of this overlap model are presented and addressed, and key next steps are suggested.
The consequences of pain: The social and physical pain overlap on psychological responses
Current theories suggest that social and physical pain overlap in their neurological and physiological outcomes. We investigated how social and physical pain overlap in their psychological responses
The Neural Bases of Social Pain: Evidence for Shared Representations With Physical Pain
TLDR
This review summarizes a program of research that has explored the idea that experiences of physical pain and social pain rely on shared neural substrates, and evidence showing that social pain activates pain-related neural regions is reviewed.
Why Social Pain Can Live on: Different Neural Mechanisms Are Associated with Reliving Social and Physical Pain
TLDR
It is observed that reliving social (vs. physical) pain led to greater self-reported re-experienced pain and greater activity in Affective pain regions (dorsal anterior cingulate cortex and anterior insula), and the degree of relived pain correlated positively with affective pain system activity.
Can Marijuana Reduce Social Pain?
Social and physical pain share common overlap at linguistic, behavioral, and neural levels. Prior research has shown that acetaminophen—an analgesic medication that acts indirectly through
From painkiller to empathy killer: acetaminophen (paracetamol) reduces empathy for pain.
TLDR
It is suggested that the physical painkiller acetaminophen reduces empathy for pain and provides a new perspective on the neurochemical bases of empathy.
A Social Analgesic? Acetaminophen (Paracetamol) Reduces Positive Empathy
TLDR
It is suggested that acetaminophen reduces affective reactivity to other people’s positive experiences and the experience of physical pain and positive empathy may have a more similar neurochemical basis than previously assumed.
Pain reduces discrimination in helping
Because of their shared neurobiological underpinnings, factors increasing physical pain can also increase feelings of social disconnection ("social pain"). Feelings of connection with a social group
Shared neural circuits: The connection between social and physical pain
TLDR
The current literature review explores the connection between social pain and physical pain in neural activity, individual differences, situation appraisal, social support, and pain reducers and concludes with a synthesis and discussion about why understanding social pain is important.
...
...

References

SHOWING 1-10 OF 41 REFERENCES
Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection
TLDR
Data suggest that the A118G polymorphism specifically, and the μ-opioid receptor more generally, are involved in social pain in addition to physical pain.
Why does social exclusion hurt? The relationship between social and physical pain.
TLDR
Evidence is reviewed showing that humans demonstrate convergence between the 2 types of pain in thought, emotion, and behavior, and that social and physical pain share common physiological mechanisms.
Alone but feeling no pain: Effects of social exclusion on physical pain tolerance and pain threshold, affective forecasting, and interpersonal empathy.
TLDR
Experiments 1-4 showed that receiving an ostensibly diagnostic forecast of a lonesome future life reduced sensitivity to physical pain, as indicated by both (higher) thresholds and tolerance, and also caused emotional insensitivity.
Potential analgesic mechanisms of acetaminophen.
TLDR
It is shown that the predominant mechanisms of APAP's analgesic effects are in the central nervous system (CNS) and endocannabinoid signaling may play a role inAPAP's activation of the serotonergic descending inhibitory pathways.
Does Rejection Hurt? An fMRI Study of Social Exclusion
TLDR
A neuroimaging study examined the neural correlates of social exclusion and tested the hypothesis that the brain bases of social pain are similar to those of physical pain, suggesting that RVPFC regulates the distress of socialclusion by disrupting ACC activity.
Asymbolia for pain: A sensory‐limbic disconnection syndrome
TLDR
The behavioral and neuroanatomical features of asymbolia for pain occurring in 6 patients following unilateral hemispheric damage secondary to ischemic lesions in 5 and traumatic hematoma in 1 suggest that insular damage may play a critical role in the development of the syndrome by interrupting connections between sensory cortices and the limbic system.
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
...
...