Acetaminophen Overdose in Pregnancy

@article{Wilkes2005AcetaminophenOI,
  title={Acetaminophen Overdose in Pregnancy},
  author={Jason M Wilkes and Larry E. Clark and Jorge Luis Herrera Herrera},
  journal={Southern Medical Journal},
  year={2005},
  volume={98},
  pages={1118-1122}
}
Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes. Fetal hepatocytes metabolize APAP into both active and toxic metabolites. These toxic metabolites may cause fetal hepatic necrosis. N-acetylcysteine (NAC) has also been demonstrated to cross the… 
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63 Citations
Highly Influential Citations
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Background Citations
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63 Citations

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Maternal acetaminophen overdose can be associated with delayed fetal compromise, suggesting the importance of continued fetal surveillance several days after ingestion.
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Given the high prevalence of use, findings regarding intrauterine exposure to acetaminophen on multiple child health outcomes raise concerns and research on causal and non-causal mechanisms that might explain these associations should be a priority.
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References

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TLDR
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TLDR
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