Acetaminophen Overdose in Pregnancy

  title={Acetaminophen Overdose in Pregnancy},
  author={Jason M Wilkes and Larry E. Clark and Jorge Luis Herrera Herrera},
  journal={Southern Medical Journal},
Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes. Fetal hepatocytes metabolize APAP into both active and toxic metabolites. These toxic metabolites may cause fetal hepatic necrosis. N-acetylcysteine (NAC) has also been demonstrated to cross the… 

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