Acetaminophen Overdose in Pregnancy

@article{Wilkes2005AcetaminophenOI,
  title={Acetaminophen Overdose in Pregnancy},
  author={J. M. Wilkes and Larry E. Clark and J. Herrera},
  journal={Southern Medical Journal},
  year={2005},
  volume={98},
  pages={1118-1122}
}
Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes. Fetal hepatocytes metabolize APAP into both active and toxic metabolites. These toxic metabolites may cause fetal hepatic necrosis. N-acetylcysteine (NAC) has also been demonstrated to cross the… Expand
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The clinical and pathophysiologic features of hepatotoxicity secondary to paracetamol are described and an update on current available knowledge and treatment options is provided. Expand
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Given the high prevalence of use, findings regarding intrauterine exposure to acetaminophen on multiple child health outcomes raise concerns and research on causal and non-causal mechanisms that might explain these associations should be a priority. Expand
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