Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man

@article{Hinz2008AcetaminophenI,
  title={Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man},
  author={Burkhard Hinz and Olga Cheremina and Kay Brune},
  journal={The FASEB Journal},
  year={2008},
  volume={22},
  pages={383 - 390}
}
For more than three decades, acetaminophen (INN, paracetamol) has been claimed to be devoid of significant inhibition of peripheral prostanoids. Meanwhile, attempts to explain its action by inhibition of a central cyclooxygenase (COX)‐3 have been rejected. The fact that acetaminophen acts functionally as a selective COX‐2 inhibitor led us to investigate the hypothesis of whether it works via preferential COX‐2 blockade. Ex vivo COX inhibition and pharma‐cokinetics of acetaminophen were assessed… 
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