Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man

  title={Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man},
  author={Burkhard Hinz and Olga Cheremina and Kay Brune},
  journal={The FASEB Journal},
  pages={383 - 390}
For more than three decades, acetaminophen (INN, paracetamol) has been claimed to be devoid of significant inhibition of peripheral prostanoids. Meanwhile, attempts to explain its action by inhibition of a central cyclooxygenase (COX)‐3 have been rejected. The fact that acetaminophen acts functionally as a selective COX‐2 inhibitor led us to investigate the hypothesis of whether it works via preferential COX‐2 blockade. Ex vivo COX inhibition and pharma‐cokinetics of acetaminophen were assessed… 
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  • 2021
The current review gives an update and in some cases challenges the different theories on the pharmacology of paracetamol and raises questions on some of the inadequately explored actions of par acetamol.
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    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2008
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  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2000
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The hypothesis that the clinical action of acetaminophen is mediated by inhibition of PGHS activity, and that hydroperoxide concentration contributes to its cellular selectivity, is supported.
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