Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study

@article{Larson2005AcetaminopheninducedAL,
  title={Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study},
  author={Ann M. Larson and Julie E Polson and Robert John Fontana and Timothy J. Davern and Ezmina Lalani and Linda S. Hynan and Joan S. Reisch and Frank Vinholt Schi{\o}dt and George Ostapowicz and Aktaruzzaman Shakil and William M. Lee},
  journal={Hepatology},
  year={2005},
  volume={42}
}
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen‐induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over a 6‐year period fulfilling standard criteria for ALF (coagulopathy and encephalopathy), from which 275 (42%) were determined to result from acetaminophen liver injury. The annual percentage of acetaminophen… Expand
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