Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study

@article{Larson2005AcetaminopheninducedAL,
  title={Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study},
  author={A. Larson and J. Polson and R. Fontana and T. Davern and E. Lalani and L. Hynan and J. Reisch and F. V. Schi{\o}dt and G. Ostapowicz and A. Shakil and William M. Lee},
  journal={Hepatology},
  year={2005},
  volume={42}
}
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen‐induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over a 6‐year period fulfilling standard criteria for ALF (coagulopathy and encephalopathy), from which 275 (42%) were determined to result from acetaminophen liver injury. The annual percentage of acetaminophen… Expand
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Paper Mentions

Observational Clinical Trial
The purpose of this study is to collect clinical and epidemiological data as well as serum, plasma, urine, tissue and DNA samples on individuals who have acute liver failure and on… Expand
ConditionsAcute Liver Failure, Acute Liver Injury, Fulminant Hepatic Failure
Interventional Clinical Trial
This Phase 2a clinical study is designed to provide data on OCR-002 in patients with acute liver failure/acute liver injury (ALF/ALI) in regard to: - safety and tolerability… Expand
ConditionsAcute Liver Failure, Acute Liver Injury
InterventionDrug
Observational Clinical Trial
The purpose of this study is to evaluate, through brief, one-on-one cognitive interviews, the efficacy of 'enhanced' acetaminophen messages and icons in improving consumer understanding… Expand
ConditionsAcetaminophen Overdose, Pain
InterventionBehavioral
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