Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells.

@article{Rollins1979AcetaminophenPT,
  title={Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells.},
  author={Douglas Rollins and Christer von Bahr and Hans Glaumann and Peter Mold{\'e}us and Anders Rane},
  journal={Science},
  year={1979},
  volume={205 4413},
  pages={1414-6}
}
A reactive metabolite of acetaminophen is hepatotoxic in humans when the drug is ingested in large overdoses. The ability of the human fetal and adult liver to oxidize acetaminophen by trapping the potentially toxic metabolite as a glutathione conjugate has been measured. Oxidation by fetal liver was approximately ten times slower than by adult liver. However, there was a definite increase in acetaminophen oxidation with fetal age. Isolated human fetal liver cells conjugated acetaminophen with… CONTINUE READING

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