Acetaminophen: The 150 mg/kg Myth

@article{Tenenbein2004AcetaminophenT1,
  title={Acetaminophen: The 150 mg/kg Myth},
  author={Milton Tenenbein},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2004},
  volume={42},
  pages={145 - 148}
}
  • M. Tenenbein
  • Published 1 January 2004
  • Medicine
  • Journal of Toxicology: Clinical Toxicology
Acetaminophen is a very common drug overdose inyoung children. For the year 2001, the AmericanAssociation of Poison Control Centers reported over25,000 telephone enquiries regarding children under theage of six who were thought to have ingested anoverdose of this drug (1). Management is based upon thereported dose that has been ingested. Recommendationsfor interventions such as activated charcoal and themeasurement of the serum acetaminophen concentrationare made once a threshold dose has been… 

Comment on “Acetaminophen: The 150 mg/kg Myth”

Comment on a recent commentary entitled: ‘‘Acetaminophen: The 150 mg/kg Myth’’ by Tenenbein, where the author criticizes a paper where the 4 h plasma concentrations of acetaminophen following an overdose in children was used to assess the efficacy of ipecac.

Reduced Toxicity of Acetaminophen in Children: It's the Liver

  • G. Bond
  • Medicine
    Journal of toxicology. Clinical toxicology
  • 2004
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Evaluation of overdose with the intravenous formulation of acetaminophen is similar to oral overdose, and health care providers are encouraged to contact their regional poison center so that dosing errors will be reported, and the experience with this new product can be accumulated.

Four-hour acetaminophen concentration estimation after ingested dose based on pharmacokinetic models

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Acetaminophen Self-Poisoning: Suicidal and Accidental

Overdose with acetaminophen in adults was often indications of suicidal behavior, and in children was usually of accidental type, and the outcome was generally good in spite of commonacetaminophen poisoning.

[Acute toxic exposure in children: an overview].

There is no evidence that gastrointestinal decontamination and multiple-dose activated charcoal improve the outcome of poisoned patients, and Ipecac syrup and cathartics should not be administered on a routine basis in acute toxic exposures in outpatient treatment.

Paracetamol overdose in the newborn and infant: a life-threatening event

This narrative review critically analyze and summarize the available literature on newborns and infants exposed to supratherapeutic doses of paracetamol, with special focus on their clinical features, outcome, and management.

The proper use of acetaminophen.

While APAP is generally considered to be safe when used as directed, its inclusion in multiple over-the-counter medications, as well as in prescription drugs, mandates that physicians promote and educate the general public about the proper use of acetaminophen in children.

Nephrotoxicity Associated with Acute Paracetamol Overdose: A Case Report and Review of the Literature

The use of NAC in this case may have prevented the progression to liver failure and reduced the severity of the nephrotoxic effects of paracetamol.

ExposiÁies tÛxicas agudas em crianÁas: um panorama Acute toxic exposure in children: an overview

There is no evidence that gastrointestinal decontamination and multiple-dose activated charcoal improve the outcome of poisoned patients, and Ipecac syrup and cathartics should not be administered on a routine basis in acute toxic exposures in outpatient treatment.

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  • Medicine
    Journal of toxicology. Clinical toxicology
  • 2000
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Acetaminophen ingestion in childhood--cost and relative risk of alternative referral strategies.

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