Acetaldehyde targets superoxide dismutase 2 in liver cancer cells inducing transient enzyme impairment and a rapid transcriptional recovery.

@article{ClavijoCornejo2014AcetaldehydeTS,
  title={Acetaldehyde targets superoxide dismutase 2 in liver cancer cells inducing transient enzyme impairment and a rapid transcriptional recovery.},
  author={Denise Clavijo-Cornejo and Mario Guti{\'e}rrez-Carrera and Mayrel Palestino-Dom{\'i}nguez and Mayra Dom{\'i}nguez-P{\'e}rez and N. Nu{\~n}o and Veronica Ferreira de Souza and Roxana Uri Miranda and David Kershenobich and Ma Concepci{\'o}n Guti{\'e}rrez-Ru{\'i}z and Leticia Bucio and Luis Enrique Gomez-Quiroz},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2014},
  volume={69},
  pages={102-8}
}
Alcohol is undoubtedly, the main toxic agent that people consume by recreation and the abuse is associated with liver damage, mainly by the overproduction of reactive oxygen species and the toxic effects of its first metabolite acetaldehyde. It is known that acetaldehyde targets mitochondria inducing redox imbalance and oxidative stress. Mitochondrial superoxide dismutase transforms superoxide radical into hydrogen peroxide, which in addition, is transformed in water by other enzymes. In the… CONTINUE READING
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