Acetaldehyde-protein adducts, but not lactate and pyruvate, stimulate gene transcription of collagen and fibronectin in hepatic fat-storing cells.

@article{Casini1993AcetaldehydeproteinAB,
  title={Acetaldehyde-protein adducts, but not lactate and pyruvate, stimulate gene transcription of collagen and fibronectin in hepatic fat-storing cells.},
  author={A Casini and Grazia Galli and Renata Salzano and Carlo Maria Rotella and Calogero Surrenti},
  journal={Journal of hepatology},
  year={1993},
  volume={19 3},
  pages={385-92}
}
Hepatic fibrosis is an important morphological feature of alcohol-induced liver injury. We previously reported that acetaldehyde, but not ethanol can stimulate type I collagen and fibronectin synthesis in cultures of rat fat-storing cells (FSC) by increasing transcription of the specific genes. The effect of lactate and pyruvate was studied on collagen I, III, fibronectin accumulation by cultured rat FSCs and it was investigated whether acetaldehyde could increase procollagen I and fibronectin… CONTINUE READING

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