Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system.

  title={Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system.},
  author={Maria Rosario Melis and Paolo Enrico and Alessandra Tiziana Peana and Marco Diana},
  journal={The European journal of neuroscience},
  volume={26 10},
Ethanol (EtOH), the main psychoactive ingredient of alcoholic drinks, is widely considered to be responsible for alcohol abuse and alcoholism through its positive motivational properties, which depend, at least partially, on the activation of the mesolimbic dopaminergic system. However, acetaldehyde (ACD), the first metabolite of EtOH, has been classically considered to be aversive and useful in the pharmacological therapy of alcoholics. Here we show that EtOH-derived ACD is necessary for EtOH… CONTINUE READING


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