Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers.

@article{Salaspuro2009AcetaldehydeAA,
  title={Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers.},
  author={Mikko P Salaspuro},
  journal={Scandinavian journal of gastroenterology},
  year={2009},
  volume={44 8},
  pages={
          912-25
        }
}
The key issue in cancer prevention is the identification of specific aetiologic factors. Acetaldehyde, the first metabolite of ethanol oxidation, is carcinogenic in animals. ADH and ALDH2 gene mutations provide an exceptional human model to estimate the long-term effects of acetaldehyde exposure in man. These models provide strong evidence for the local carcinogenic potential of acetaldehyde also in humans. Ethanol is metabolized to acetaldehyde by both mucosal and microbial enzymes. Many… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 52 CITATIONS, ESTIMATED 49% COVERAGE

Catalytic removal of acetaldehyde in saliva by a Gluconobacter strain.

  • Journal of bioscience and bioengineering
  • 2012
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Reducing carcinogenic acetaldehyde exposure in the achlorhydric stomach with cysteine.

  • Alcoholism, clinical and experimental research
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND

Little Cigars, Filtered Cigars, and their Carbonyl Delivery Relative to Cigarettes

  • Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 2018

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 6 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 134 REFERENCES

Carcinogenicity of alcoholic beverages.

  • The Lancet. Oncology
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China

Yang S-J, Wang H-Y, +3 authors Chen H-G
  • World J Gastroenterol 2007;/13:/5760
  • 2007
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL