Acentrosomal Drosophila epithelial cells exhibit abnormal cell division, leading to cell death and compensatory proliferation.

@article{Poulton2014AcentrosomalDE,
  title={Acentrosomal Drosophila epithelial cells exhibit abnormal cell division, leading to cell death and compensatory proliferation.},
  author={John S. Poulton and John C Cuningham and Mark Peifer},
  journal={Developmental cell},
  year={2014},
  volume={30 6},
  pages={731-45}
}
Mitotic spindles are critical for accurate chromosome segregation. Centrosomes, the primary microtubule nucleating centers of animal cells, play key roles in forming and orienting mitotic spindles. However, the survival of Drosophila without centrosomes suggested they are dispensable in somatic cells, challenging the canonical view. We used fly wing disc epithelia as a model to resolve these conflicting hypotheses, revealing that centrosomes play vital roles in spindle assembly, function, and… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS