Acellular Pertussis Booster in Adolescents Induces Th1 and Memory CD8+ T Cell Immune Response

@inproceedings{Rieber2011AcellularPB,
  title={Acellular Pertussis Booster in Adolescents Induces Th1 and Memory CD8+ T Cell Immune Response},
  author={Nikolaus Rieber and Anna Graf and Dominik Hartl and Simon Urschel and Bernd H. Belohradsky and Johannes Liese},
  booktitle={PloS one},
  year={2011}
}
In a number of countries, whole cell pertussis vaccines (wcP) were replaced by acellular vaccines (aP) due to an improved reactogenicity profile. Pertussis immunization leads to specific antibody production with the help of CD4(+) T cells. In earlier studies in infants and young children, wcP vaccines selectively induced a Th1 dominated immune response, whereas aP vaccines led to a Th2 biased response. To obtain data on Th1 or Th2 dominance of the immune response in adolescents receiving an aP… CONTINUE READING

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Vaccines, 5th Edition

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