Acellular Bordetella pertussis vaccine enhances mucosal interleukin-10 production, induces apoptosis of activated Th1 cells and attenuates colitis in Galphai2-deficient mice.

Abstract

Mice deficient for the inhibitory G protein subunit alpha2 (Galphai2(-/-)) spontaneously develop a progressive inflammatory bowel disease resembling ulcerative colitis, and have a T helper 1 (Th1)-dominated immune response prior to onset of colitis, which is further augmented after the onset of disease. The present study was performed to investigate whether… (More)

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@article{Ohman2005AcellularBP, title={Acellular Bordetella pertussis vaccine enhances mucosal interleukin-10 production, induces apoptosis of activated Th1 cells and attenuates colitis in Galphai2-deficient mice.}, author={Lena Ohman and Roger Will{\'e}n and Olof H Hultgren and Elisabeth Hultgren H{\"{o}rnquist}, journal={Clinical and experimental immunology}, year={2005}, volume={141 1}, pages={37-46} }