Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac

@article{Hinz2003AceclofenacSC,
  title={Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac},
  author={B. Hinz and T. Rau and D. Auge and U. Werner and R. Ramer and S. Rietbrock and K. Brune},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2003},
  volume={74}
}
  • B. Hinz, T. Rau, +4 authors K. Brune
  • Published 2003
  • Chemistry, Medicine
  • Clinical Pharmacology & Therapeutics
The mechanism of action of aceclofenac is currently unclear. This study investigated whether biotransformation to metabolites (4′‐hydroxy‐aceclofenac, diclofenac, 4′‐hydroxy‐diclofenac) contributes to inhibitory effects on the cyclooxygenase (COX) isozymes in vitro and ex vivo. 
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic
  • B. Hinz, O. Cheremina, +4 authors K. Brune
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2007
Modeling of aceclofenac metabolism to major metabolites in healthy volunteers.
Drug Insight: cyclo-oxygenase-2 inhibitors—a critical appraisal
A Nonsteroidal Antiinflammatory Drug : Aceclofenac
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