Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac.


OBJECTIVE The mechanism of action of aceclofenac is currently unclear. This study investigated whether biotransformation to metabolites (4'-hydroxy-aceclofenac, diclofenac, 4'-hydroxy-diclofenac) contributes to inhibitory effects on the cyclooxygenase (COX) isozymes in vitro and ex vivo. METHODS In vitro investigations were performed with human whole… (More)